coloradocancerinfo.com - Blood and Genitourinary Cancer Update | Insight from Denver oncologist Dr. John Burke

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Title:

Blood and Genitourinary Cancer Update | Insight from Denver oncologist Dr. John Burke
Age:

2 years old
Alexa Rank:
Total Sites Linking In (Alexa):

0
Domain's IP Country:

United States
Status Code:

OK
IP Address:

192.0.78.24
Description:

Insight from Denver oncologist Dr. John Burke
Keywords:

coloradocancerinfo.com Whois Information:

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Domain Name:

coloradocancerinfo.com
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Domain Age:

2 years old
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ns1.wordpress.com
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ns2.wordpress.com
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Created:

Wednesday 22. January 2014
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Sunday 22. January 2017
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Wild West Domains, LLC

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Can radiation therapy be omitted in all early-stage patients?
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If radiation therapy cannot be omitted in all early-stage patients, then can a negative PET/CT scan after 2 cycles be used to select the patients in whom to omit radiation therapy?
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Treatment Group
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1-year PFS
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Results Significant?
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Treatment Group
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Number of Patients
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1-year PFS
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Results Significant?
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If an interim PET/CT scan after 2 cycles of ABVD is negative for residual disease, is it safe to omit the bleomycin in subsequent cycles?
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Insight from Denver oncologist Dr. John Burke
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I am a hematologist/oncologist practicing in the southeast Denver metro area at Rocky Mountain Cancer Centers. My clinical practice is now restricted to blood cancers (lymphoma, leukemia, myeloma) and genitourinary cancers (prostate, kidney, bladder, testis). I intend to use this website to keep my patients and other interested readers informed about updates in these cancers.
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Can radiation therapy be omitted in all early-stage patients?
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If no, then can a negative PET/CT scan after 2 cycles be used to select the patients in whom to omit radiation therapy?
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If an interim PET/CT scan after 2 cycles of ABVD is negative for residual disease, is it safe to omit the bleomycin in subsequent cycles?
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If an interim PET/CT scan after 2 cycles of ABVD is positive for residual disease, then is it helpful to change the ABVD to the more aggressive âescalated BEACOPPâ regimen for the remaining 4 cycles?
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Dropping the bleomycin reduced the rate of infections and pulmonary toxicity.
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Dropping the bleomycin did not affect the 3-year progression-free survival (84-85% in both arms).
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Dropping the bleomycin did not affect the 3-year overall survival (97% in both arms).
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Can radiation therapy be omitted in all early stage patients? I still feel like the answer is not really known. The NCIC HD6 trial clearly demonstrated that
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Can a negative PET/CT scan after 2 cycles (interim PET) be used to select the patients in whom to omit radiation therapy? My answer is maybe. Patients with a negative interim PET who omit radiation therapy have a slightly higher risk of relapse. However, patients who relapse are often saved by additional chemotherapy, autologous stem cell transplant, and/or radiation therapy. It is possible that the higher risk of relapse will translate to one of the following:
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Lower overall survival due to deaths from relapsed Hodgkin lymphoma.
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Equal or improved overall survival due to effective salvage therapy and less radiation-related toxicity.

coloradocancerinfo.com IP Information:

1.

Ip Address:

192.0.78.24
2.

Country:

United States
3.

Status Code:

OK
4.

Region Name:

California
5.

City Name:

San Francisco
6.

Zip Code:

94110
7.

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9.66 ms

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Top Keywords from Search Engines:
clinical care options, fcr chemotherapy, lgh-447, clinicalcareoptions

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